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- فارسی
One-pot synthesis of 2, 4, 5-triaryl-1H-imidazoles linked 1, 4-disubstituted 1, 2, 3-triazoles based on a merging multicomponent condensation with Huisgen 1, 3-dipolar cycloaddition in ionic liquid
M. Dabiri*, S.K. Movahed, D.I. MaGee (2015) Research on Chemical Intermediates 41 (6), 3335-3347.
https://doi.org/10.1007/s11164-013-1436-1
Abstract
A new and efficient approach for the synthesis of 2,4,5-triaryl-1H-imidazoles linked 1,4-disubstitued 1,2,3-triazoles have been developed by multicomponent condensation with Huisgen 1,3-dipolar cycloaddition. A mixture of aromatic propargylated aldehydes, different azides, benzil, and ammonium acetate were condensed in the presence of catalytic amounts of acidic ionic liquid, 1-methylimidazolium trifluoroacetate, ([Hmim]TFA), and Cu(OAc)2/sodium ascorbate to afford the corresponding products. The features of this procedure are operational simplicity, good yields of products, and solvent-free conditions.