Pd-Catalyzed regioselective C–H halogenation of quinazolinones and benzoxazinones

M. Dabiri*, N.F. Lehi, S.K. Movahed, H.R. Khavasi (2017) Organic & Biomolecular Chemistry 15 (29), 6264-6268.

https://doi.org/10.1039/C7OB01534H

Abstract

A Pd-catalyzed ortho-selective halogenation of benzoxazinone and quinazolinone scaffolds has been described employing N-halosuccinimide as both a halogen source and an oxidant reagent via C–H bond activation. This transformation shows high chemo- and regioselectivities and demonstrates a broad range of benzoxazinone and quinazolinone substrates with different functional groups and has been scaled up to the gram level.