One-pot synthesis of 1,2,3-triazole linked dihydropyrimidinones via Huisgen 1,3-dipolar/Biginelli cycloaddition

P Salehi, M Dabiri*, M Koohshari, S.K. Movahed, M Bararjanian (2013) Molecular diversity 15 (4), 833-837.

https://doi.org/10.1007/s11030-011-9313-6

Abstract 

The combination of the Biginelli reaction with click chemistry has been used for the one-pot synthesis of 1,2,3-triazole linked dihydropyrimidinones from azides, aromatic aldehydes containing a propargyl ether group, urea, and 1,3-dicarbonyl compounds using Cu(OAc)₂/sodium ascorbate as catalyst in acetic acid under mild reaction conditions.