Palladium‐Catalyzed Direct ortho‐C–H Bond Sulfonylation and Halogenation of Phthalazine‐1,4‐diones

M. Dabiri,* N. F. Lehi, C. Osmani, S. K. Movahed (2019) European Journal of Organic Chemistry 2019, 7247–7254.

https://doi.org/10.1002/ejoc.201901055

Abstract

The regio- and chemo-selective Pd-catalyzed C–H activation methods have been successfully reported for directed C–H sulfonation and halogenation of pyridazinedione with arylsulfonyl chlorides and N-halosuccinimide, respectively. These protocols are compatible with a range of various functional groups and exhibit excellent regio-selectivity under mild reaction conditions by use of inexpensive and readily accessible reagents.